Highlight of Breakthrough in Lung-Targeted mRNA Delivery for Treating Pulmonary Injuries

Feb 24, 2025. Zipcode Bio is pleased to spotlight a recent publication by our co-founder's team in Nature Communications, titled Targeted delivery of TGF-β mRNA to murine lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers, that presents significant advancements in lung-targeted mRNA delivery as a therapeutic strategy for pulmonary injuries.

The promising therapeutic outcomes observed in animal studies underscore the potential of this technology to revolutionize treatments for respiratory conditions. By overcoming existing challenges in nucleic acid delivery, this delivery platform offers a streamlined solution that could pave the way for new mRNA-based therapies targeting lung diseases.